CFB-GBM v2.0: An Augmented Longitudinal Dataset for Multi-Modal Glioblastoma Segmentation, Radiomics, and RANO Progression Tracking
초록
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a median overall survival of 15 months. Longitudinal, multi-modal imaging datasets with comprehensive clinical and treatment data are essential to support the development of reproducible computational methods for treatment response prediction, disease progression modelling, and personalized medicine. We present CFB-GBM v2.0, an extension of our previously released CFB-GBM dataset comprising 264 GBM patients treated according to the standard Stupp protocol. The primary contribution of this release is the completion of Gross Tumour Volume (GTV) delineations across all available timepoints ($t_0$, $t_1$ and $t_2$), increasing the overall GTV completion rate from 35% to 97%. This was achieved using a nnU-Net model pre-trained on BraTS 2021 and fine-tuned on CFB-GBM ground-truth contours, with the generated segmentations validated by five radiation oncologists. From these longitudinal GTV annotations, volumetric RANO 2.0 response category labels were derived for all available temporality pairs ($t_0 \rightarrow t_1$, $t_0 \rightarrow t_2$ and $t_1 \rightarrow t_2$). To further ease dataset usability and reproducibility, brain masks computed with HD-BET and pre-computed radiomic features extracted with PyRadiomics are provided for each patient timepoint and MRI modality. Additionally, the WHO classification guideline (2016 vs. 2021) applicable to each patient's diagnosis is now explicitly documented. CFB-GBM v2.0 is publicly available on The Cancer Imaging Archive (TCIA) at https://www.cancerimagingarchive.net/collection/cfb-gbm .
저자 (24명)
- Alexandre G. Leclercq — LinkedIn 검색
- Noémie N. Moreau — LinkedIn 검색
- Hugo Audebert — LinkedIn 검색
- Andros Nassar — LinkedIn 검색
- Thomas Cochin — LinkedIn 검색
- Thomas Leleu — LinkedIn 검색
- Loïc Le Henaff — LinkedIn 검색
- Alexis Desmonts — LinkedIn 검색
- Yoann Poirier — LinkedIn 검색
- Aurélie Dubru — LinkedIn 검색
- Laura Guillemette — LinkedIn 검색
- Pascal Lecoeur — LinkedIn 검색
- Kévin Lemasson — LinkedIn 검색
- Cyril Jaudet — LinkedIn 검색
- Sébastien Bougleux — LinkedIn 검색
- Romain Hérault — LinkedIn 검색
- Carole Brunaud — LinkedIn 검색
- Samuel Valable — LinkedIn 검색
- Dinu Stefan — LinkedIn 검색
- Charlotte Raboutet — LinkedIn 검색
- Alain Batalla — LinkedIn 검색
- Joëlle Lacroix — LinkedIn 검색
- Roman Rouzier — LinkedIn 검색
- Aurélien Corroyer-Dulmont — LinkedIn 검색
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